Systemic amyloidosis is underdiagnosed in light-chain amyloidosis (AL), as is plasma cell dyscrasias (PCD). Early detection and accurate evaluation of organ involvement in systemic amyloidosis remain critical challenges. We aimed to assess the utility of [18F]florbetapir (FBP) and [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) for the early detection and evaluation of organ involvement in systemic amyloidosis.
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Refining the Tmax malignant profile in large ischemic core patients receiving endovascular treatment
A significant proportion of patients with large ischemic core volume (LICV) have poor outcome despite successful recanalization. We aimed to assess the optimal cutoff for hypoperfusion volume, defined as Tmax > 6-seconds lesion size, to identify a malignant profile in LICV patients and predict poor functional outcome after endovascular treatment (EVT).
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Photon-counting CT: An updated review of clinical results
The introduction of photon-counting computed tomography (PCD-CT) in clinical practice at the end of 2021 symbolizes a paradigm shift in medical imaging. PCD-CT merges superior spatial resolution, spectral separation, and dose efficiency into a single technology, tackling the challenges of energy-integrating detector (EID) CT such as noise and energy binning inefficiencies [1,2].
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Vascular lesions of head and neck region: A pictorial review
Vascular lesions in the head and neck region have variable appearances and an extensive pathological spectrum. These lesions include many malformations and tumors, ranging from hemangiomas to arterio-venous fistulas [1–3]. Until now, there have been different classification systems based on various characteristics of lesions including histologic appearance, flow rate, and deep or superficial position in the region. The classification introduced by the International Society for the Study of Vascu…
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What looks like a contrast reaction may not be a contrast reaction
Adverse reactions following the application of a contrast medium are always a challenge for radiologists. To date, little consideration has been given to causality analyses. Hypersensitivity reactions in the context of contrast-enhanced imaging procedures may be caused by the contrast agent, but other culprit agens (such as latex allergy) should be also considered.
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Non-invasive CT based multiregional radiomics for predicting pathologic complete response to preoperative neoadjuvant chemoimmunotherapy in non-small cell lung cancer
This study aims to develop and validate a multiregional radiomics model to predict pathological complete response (pCR) to neoadjuvant chemoimmunotherapy in non-small cell lung cancer (NSCLC), and further evaluate the performance of the model in different specific subgroups (N2 stage and anti-PD-1/PD-L1).
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Evaluation of recall rates in the Irish national breast screening programme: Insights from two million screening mammograms
Population-based breast screening aims to reduce breast cancer mortality and morbidity through early detection and treatment [1]. Mammography, the most widely used screening method, is associated with an estimated 20 % reduction in breast cancer mortality within the screened population [2,3]. However, debate persists around the benefits and harms of breast cancer screening [2]. Effective screening relies on maximising benefits i.e., reduced mortality and morbidity whilst minimising harms i.e., a…
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Improving the diagnostic accuracy of small renal masses: Integration of radiomics and clear cell likelihood scores in multiparametric MRI
Accurate diagnosis of small renal masses is crucial for treatment planning. Combining radiomics analysis with the Clear Cell Likelihood Score (ccLS) in multiparametric MRI can effectively assess malignancy risk. This study aimed to evaluate the contribution of MRI-based radiomics analysis to the diagnostic performance of the ccLS in differentiating clear cell renal carcinoma (ccRCC).
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A practical approach to quality improvement in medium sized radiology departments
In the evolving field of medical imaging, the fast pace of technological advancements necessitates frequent updates to imaging protocols. With, as an example, PubMed adding close to one million new papers annually, the medical research field as a whole has experienced significant yearly growth of 8–9 % over the last decades [1]. Despite this influx of knowledge, translating research findings into clinical radiological practice remains a challenge [2,3]. One study observed that after 17 years onl…
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Personalized high pitch CTPA facilitates a reduction of contrast agent volume
Despite advancements in computed tomography pulmonary angiography (CTPA), optimizing contrast agent (CA) volume remains crucial due to inter-patient hemodynamic variability. This study aimed to evaluate a personalized scan delay approach using a test bolus technique to minimize CA volume while maintaining diagnostic image quality.