A critical therapeutic approach that is effective for locally advanced rectal cancer (LARC) is to formulate individualized treatment strategies following neoadjuvant chemoradiotherapy (nCRT) on the basis of locoregional and systemic tumor response (“watch-and-wait” approach) [1,2]. Despite ongoing controversies, this strategy can reduce surgery-related and functional complications, thereby benefiting patients [1,3,4]. However, significant individualized differences in therapeutic responses exist…
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Comment on “ Analysis of clinical and imaging characteristics of pseudocirrhosis in breast cancer liver metastasis”
The interesting paper by L. Deng et al. [1], which updates the diagnostic radiological imaging of neoplastic pseudocirrhosis (NPC) in breast cancer liver metastasis, merits further exploration from a pathophysiological perspective. This would help us to better understand this pathology, which often indicates an advanced stage of different neoplastic diseases. In order for a liver disease to be classified as an NPC, two criteria must be met: metastatic liver involvement and clinical signs that mi…
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Automatic phantom-less QCT predicts hip fracture risk: Bone and muscle parameters comparison
Hip fractures are a severe consequence of osteoporosis, posing substantial health risks to older adults worldwide [1,2]. By 2050, the global number of hip fractures among older adults is projected to reach 4.5 million [3], with 20-24 % of patients dying within 1 year of hip fracture [2,4] and most survivors failing to regain pre-fracture functional levels [5].Therefore, early identification of individuals at high risk is essential for implementing preventive strategies.
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mpMRI-based interpretable machine learning model for predicting castration-resistant prostate cancer risk
Prostate cancer (PCa) is the second most common cancer among men worldwide [1]. Due to the subtle nature of early symptoms, most patients are diagnosed at an advanced stage.Androgen deprivation therapy (ADT) remains the cornerstone treatment for locally advanced and metastatic prostate cancer (mPCa) [2]. Although most patients eventually progress to castration-resistant prostate cancer (CRPC), the duration of CRPC progression varies between individuals [3,4]. Accurately predicting CRPC time befo…
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Early Intensive GDMT Regimen May Boost Recovery in HFrEF
Early and intensive guideline-directed medical therapy shows the recovery of heart function within 3 months among patients newly diagnosed with heart failure with markedly reduced ejection fraction. Medscape News UK
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Optimizing knee MRI: 3D proton density turbo spin echo nDixon sequence vs. 2D high-resolution turbo spin echo in half the acquisition time
Two-dimensional (2D) multiplanar turbo spin-echo (TSE) acquisitions have been the gold standard in knee MRI for decades [1,2]. Although TSE MRI has been accelerated by parallel and simultaneous multi-slice imaging with an acquisition time as low as 5 min, three-dimensional (3D) MRI has become an integral part of clinical protocols [3]. The initial application of 3D MRI was to evaluate articular cartilage, detecting small chondral lesions that were difficult to detect on 2D imaging due to partial…
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Late gadolinium enhancement in patients with and without autoimmune rheumatic diseases: “walking, we create the way”
“There is no way! Walking, we create the way.” −Antonio Matsado, Spanish Poet
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Enhanced opportunistic CT screening for osteoporosis using Machine learning derived volumetric vertebral and complementary body composition information
Osteoporosis is a major disease of bone metabolism characterized by decreased bone mass and impaired bone microarchitecture. The diagnosis of osteoporosis is based on measuring bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA), with a BMD T-score of −2.5 or lower, as defined by the WHO diagnostic criteria for osteoporosis, representing the threshold for diagnosis [1,2]. Two sites are typically measured: the lumbar spine, including the frontal projection of the L1 to L4 vert…