Image-guided biopsies are essential for confirming diagnoses, staging disease, and assessing treatment response. Although generally safe, percutaneous biopsies carry a risk of serious complications, including major bleeding, organ injury, prolonged hospitalization, and, rarely, death. For example, percutaneous liver biopsy is associated with a major complication rate of approximately 2.4%, with a mortality rate of around 0.01% [1], whereas CT-guided transthoracic lung biopsy has a major complica…