Diagnostic accuracy of contrast-enhanced mammography (CEM) for the evaluation of mammographic asymmetries: A systematic review and meta-analysis

Breast cancer remains the most frequently diagnosed malignancy and a leading cause of cancer-related mortality among women worldwide [1]. Mammography is the cornerstone of screening and diagnostic imaging, yet its sensitivity is limited in dense breast tissue [2]. Architectural distortions and focal asymmetries pose diagnostic challenges, as they may represent benign variations, overlapping tissue, or malignancies [3]. While asymmetries are often managed with Supplemental imaging or biopsy, up t…

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