White Matter (WM) functional networks offer insight into the network processes underlying progression along the Alzheimer’s disease (AD) continuum. Amyloid (Aβ) retention in WM regions, as measured by Aβ-PET, reflects WM integrity and is associated with cognition. This study used simultaneous PET/MR imaging to investigate topographic alterations in WM functional networks and Aβ-burden networks, aiming to provide objective neuroimaging evidence of white matter–related pathology in Alzheimer’s dis…