We read with great interest the recent article by Vega et al. titled “Allergological evaluation of hypersensitivity reactions after administration of contrast agents: What the radiologist needs to know” [1]. The authors comprehensively addressed diagnostic algorithms for contrast-induced hypersensitivity. However, we wish to highlight an aspect that warrants further consideration: the role of polyethylene glycol (PEG) in hypersensitivity reactions to sulphur hexafluoride microbubbles (SonoVue®),…