Cerebral small vessel disease (CSVD) is highly prevalent in the elder population and is implicated in approximately 30 % of strokes and the majority of vascular dementia [1,2]. Due to a diverse range of its pathophysiology, various abnormal manifestations are observed on MRI, including white matter hyperintensities (WMH), lacunes, cerebral microbleeds, enlarged perivascular spaces (EPVS), small subcortical infarcts, brain atrophy[3]. While vascular risk factors such as aging and hypertension are…