The 5th Edition of the World Health Organization classification of Central Nervous System tumors was published online in late 2021 and included many changes both to the overall schema of the classification of many common conditions as well many changes to specific diagnoses. Additionally, a number of new entities have been recognized. Many editors and contributors, first and foremost two Francesci (Francesco Buemi and Francesco (Frank) Gaillard), reviewed and updated over 100 articles, wrote ove…