Colorectal cancer is the third most common cancer worldwide, and the liver is the primary site for metastases [1]. Surgical resection with perioperative chemotherapy is currently the cornerstone in treating colorectal liver metastases (CRLM) [2]. Preoperative systemic therapy has proven to be critical, demonstrating significant efficacy in tumor downsizing, micrometastases sterilization, and patient selection [3–6]. The modification of CRLM during chemotherapy is one of the strongest determinant…