Intravascular imaging-based coronary artery modelling is today considered as the optimal approach to assess plaque morphology and examine the effect of the local hemodynamic forces on plaque progression.1 The high-fidelity models reconstructed from intravascular imaging data enable accurate evaluation of the wall shear stress (WSS) distribution, characterization of plaque phenotypes and assessment of the changes in plaque composition. However, invasive imaging has also significant limitations as…