Acute ischemic stroke (AIS) is the leading cause of morbidity and mortality worldwide, accounting for over 80% of all stroke incidents [1]. Early detection of the location and extent of infarction is essential for making treatment decisions in AIS [2]. Specifically, the presence or absence of intracranial large vessel occlusion (LVO) is one diagnostic key element guiding the therapeutic approach in AIS. A previous study reported that the AIS patients with LVO are less likely to benefit from intr…