For patients with unresectable hepatocellular carcinoma (uHCC), the novel regimen of combining transarterial chemoembolization (TACE) with hepatic arterial infusion chemotherapy (HAIC), supplemented by immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs), has brought new hope for treatment. However, individual differences are significant. Some patients do not benefit from the treatment but instead bear the toxicity of the drugs and the economic burden. Accurate prediction of…