Mechanical stimuli, mediated by the activation of Piezo ion channels, drive many physiological processes including cardiovascular functions and disease progression.1 Significant efforts have therefore been devoted to quantifying mechanical loads within the cardiovascular system. Determining wall shear stress (WSS) and vessel structural stress (VSS), along with derived parameters such as the oscillatory shear index (OSI), relative residence time (RRT) and stress gradient, requires detailed knowle…