Gradient magnitude-based texture feature of the entorhinal cortex as a biomarker for Alzheimer’s disease

Alzheimer’s disease (AD), the most common type of dementia, is characterized by a gradual decline in cognitive function due to the progressive accumulation of physiological alterations and damage to neurons [1]. As the disease advances, it affects not only memory but also language, judgment, and the ability to perform everyday activities, ultimately leading to a stage where even simple daily tasks become unmanageable [2]. Mild cognitive impairment (MCI) represents a transitional stage preceding …

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