The central vein sign (CVS) is a neuroimaging biomarker in multiple sclerosis (MS) reflecting perivenular demyelination on pathology [1,2]. When standard T2-weighted (T2w) sequences are combined with susceptibility-sensitive MRI techniques, it is possible to visualize both the central vein and the T2w hyperintense lesions characteristic for MS. Techniques such as the FLAIR* enable concurrent visualization of the T2w hyperintense lesions and veins employing 3D T2w FLAIR and T2*-weighted (T2*w) 3D…