Chronic pancreatitis (CP) is an inflammatory disease characterized by progressive and irreversible damage to the pancreas. It imposes a significant burden on patients and healthcare systems due to severe complications, including persistent abdominal pain, diabetes, and exocrine pancreatic insufficiency (EPI) [1,2]. Modern pathophysiology models, especially mechanistic framework suggested by Whitcomb et al., depict CP as a dynamic continuum that starts with a single episode of acute pancreatitis,…