Knee osteoarthritis (KOA) remains one of the most prevalent musculoskeletal disorders worldwide, representing a primary cause of chronic pain and long-term disability among middle-aged and older adult populations [1]. Current epidemiological projections indicate a concerning rise in the global burden of KOA, with an estimated increase of 74.9 % (range: 59.4 %–89.9 %) by 2050, compared to 2020 figures [2]. Beyond its clinical impact, KOA constitutes a substantial driver of healthcare expenditures…