Exploring white matter abnormalities in different subtypes of spastic cerebral palsy using fixel-based analysis

Cerebral palsy (CP) is a neurological disorder characterized by impaired movement and posture, resulting from permanent brain damage before, during [1] or after birth [2]. About 80-90% of individuals with CP have spasticity, such as hemiplegia, diplegia, or quadriplegia depending on which limb is affected[3]. White matter damage in cerebrum, particularly periventricular leukomalacia (PVL), is commonly observed in individuals with spastic CP [4]. PVL may include focal and diffuse components, such…

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