ChatGPT-5–Based large language model analysis versus an FDA-approved AI-CAD system for thyroid nodule ultrasound evaluation

Overdiagnosis and overtreatment of thyroid nodules remain pressing clinical concerns because a substantial proportion of surgically resected lesions prove benign on histopathology [1,2]. In the U.S., cancer statistics for 2025 estimate approximately 44,000 new thyroid cancer diagnoses and about 2,300 deaths, reinforcing its status as the most common endocrine malignancy and underscoring the need for precise preoperative risk stratification to minimize unnecessary surgery and guide surveillance […

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