Automated lung texture analysis for assessing interstitial lung disease in systemic sclerosis: Diagnostic accuracy in photon-counting-detector and conventional energy-integrating-detector CT

Interstitial lung disease (ILD) is a frequent organ manifestation of systemic sclerosis (SSc), a rare but severe autoimmune connective tissue disorder [1]. The pathogenesis involves abnormal immune system activation, injury to endothelial and epithelial cells, and fibroblast activation leading to excessive collagen accumulation and thickening of the skin and internal organs, including the lungs [2]. Pulmonary manifestations remain the leading cause of death in SSc [3]. Early detection and timely…

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