Adult-type diffuse gliomas, a group of heterogenous tumors, are the most common primary tumors of central nervous system (CNS), and the treatment reaction and prognosis vary among different subgroups [1,2]. As a group of highly heterogeneous tumors, hundreds of molecular alterations have been discovered in the past 3 decades in the research of glioma biology [2–4]. Among those alterations, isocitrate dehydrogenase (IDH) mutation status and chromosome arms 1p and 19q (1p19q) codeletion status are…