Adult-type diffuse gliomas are the most common primary malignant tumors of the adult brain parenchyma [1]. With the updates to the World Health Organization classification of central nervous system tumors (WHO CNS) in 2016 and 2021, molecular profiling has become increasingly important in the diagnosis and grading of gliomas [2,3]. Distinct molecular markers and grades exhibit varying biological behaviors and show significant differences in sensitivity to radiotherapy and chemotherapy [4]. Addit…