Heart failure with preserved ejection fraction (HFpEF) already accounts for approximately 50 % of patients with the clinical syndrome of heart failure (HF) and is associated with poor quality of life and premature mortality [1]. Hypertrophic cardiomyopathy (HCM) is the most common inherited primary cardiomyopathy with an approximate prevalence of one in 500 [2]. Although life expectancy is normal for the majority of patients with HCM due to the application of contemporary cardiovascular treatmen…