This study demonstrated that QFR tends to have higher values in proximal bifurcations compared with FFRCTand μFR, which can underestimate lesion severity. Clinicians should, therefore, be aware of the methodological nuances and potential variability when selecting and interpreting these tools. Classification of lesions as focal or diffuse based on virtual pullback indices showed poor concordance across the three methods, highlighting methodological differences in phenotype characterization. Thes…