Limited linkage between epidermal growth factor receptor (EGFR) mutations and recurrence–predictive radiomic signatures restricts the application of radiomics–guided therapy for brain metastases (BMs) from non–small–cell lung cancer (NSCLC). This study aimed to establish an EGFR-associated radiomic signature (EGFR-RS), compare its consistency with that of conventional whole radiomic features-based radiomic signature (WF-RS), and evaluate its efficacy in predicting local recurrence for BMs treate…