Ischemic stroke is the most common subtype of stroke, associated with high morbidity, disability, and mortality rates [1,2]. Malignant cerebral edema (MCE) is a life-threatening complication occurring within 2–5 days after a large hemispheric infarction, leading to elevated intracranial pressure, rapid neurological deterioration, and brain herniation and a mortality rate of 40 %-80 % [3,4]. Early identification of patients at risk of developing MCE is critical to enable timely management strateg…