Langerhans cell histiocytosis (LCH) is a rare disorder of myeloid dendritic cells and characterized by tissue infiltration of CD1a+/CD207 + dendritic cells and inflammatory cells. It is more common in young children than adults [1]. The clinical manifestations and outcomes of pediatric LCH are highly heterogeneous [2], ranging from isolated and self-limited skin or bone lesion to multisystem life-threatening disseminated diseases [3]. Various organs can be affected, including bone, skin, lungs, …