Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death among women globally [1]. Neoadjuvant chemotherapy (NAC) had become a standard treatment for locally advanced breast cancer during the past decades [2]. Achieving pathologic complete response (pCR) following NAC is a predictor of an improved disease free and overall survival [3,4]. Thus, early and accurate pCR prediction can prevent needless toxicity in individuals who do not respond to treatment and…