Colon cancer is one of the most prevalent malignancies, with right-sided and left-sided colon cancers exhibiting distinct clinicopathological and molecular characteristics that influence their behaviour and prognosis. A key difference lies in the prevalence of microsatellite instability-high (MSI), a condition resulting from a deficiency of the mismatch repair (MMR) system or inactivation of the MMR system by hypermethylation of the MLH1 gene. MSI is more common in right-sided colon cancer, with…