Coronary Artery Disease (CAD) is the leading cause of mortality worldwide, accounting for 8.9 million annual deaths, and consists in the formation of atherosclerotic plaques in the arterial wall of coronary arteries [1]. Coronary plaque progression may determine coronary lumen stenosis, impairing blood supply to the myocardium, thus potentially causing major adverse cardiac events (MACE) [2]. The timely and accurate identification of the high-risk coronary plaques is crucial for stratifying pati…