Colorectal cancer (CRC) introduces a substantial health burden on patients and society due to its relatively high incidence and mortality [1]. In 2020, CRC was the third most commonly diagnosed cancer worldwide, accounting for about 10 % of all new cancer cases [2]. Moreover, CRC was the second leading cause of cancer mortality and accounted for 9.4 % of all cancer-related deaths [2]. Approximately 15–25 % of all patients with CRC history have metastatic disease (mCRC). The liver is the most com…