Explainable classification of Parkinson’s disease with different motor subtypes by analyzing the synthetic MRI quantitative parameters of subcortical nuclei

Parkinson’s Disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease, affecting 2–3 % of individuals aged 65 and older and an estimated 7–10 million people worldwide [1,2]. Clinically, PD is categorized into Tremor-Dominant (TD), Postural Instability and Gait Difficulty (PIGD), and mixed subtypes based on the MDS Unified Parkinson’s Disease Rating Scale (UPDRS). PIGD progresses more rapidly, is associated with more non-motor symptoms, and responds less effectiv…

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