Iron overload is a major complication arising from chronic transfusion-dependent disorders or abnormal intestinal iron absorption, which can lead to multi-organ dysfunction [1]. Thalassemia serves as a classic example of transfusion-dependent diseases. Globally, approximately 1.5 % of the population carries the β-thalassemia gene, with over 300,000 individuals in China diagnosed with severe or intermediate forms of the disease [2]. Patients with severe β-thalassemia exhibit an exogenous iron int…