Automated vertebrae identification and segmentation with structural uncertainty analysis in longitudinal CT scans of patients with multiple myeloma

Multiple Myeloma (MM) is an uncommon hematological malignancy characterized by uncontrolled proliferation of malignant plasma cells within the bone marrow, causing, among other symptoms, lytic bone lesions and deterioration of skeletal integrity [1]. Typically, the disease causes excessive bone resorption leading to vertebral compression fractures (VCFs), which 55 %-70 % of the patients suffer from at diagnosis [2]. The quality of life after such events decreases considerably, underscoring the i…

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