As a new noninvasive diagnostic technique, computed tomography-derived fraction flow reserve (FFRCT) has been used to identify hemodynamically significant coronary artery stenosis. FFRCT can be calculated using computational fluid dynamics (CFD) or machine learning (ML) approaches. It was hypothesized that ML-based FFRCT (FFRCTML) has comparable diagnostic performance with CFD-based FFRCT (FFRCTCFD). We used invasive FFR as the reference test to evaluate the diagnostic performance of FFRCTML vs.